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ORIGINAL ARTICLE
Year : 2015  |  Volume : 15  |  Issue : 1  |  Page : 26-30

A comparative study of functional pulmonary involvement in patients with rheumatoid arthritis in a semi-urban population of Eastern India


Department of Physiology, Burdwan Medical College and Hospital, Burdwan, West Bengal, India

Correspondence Address:
Arunima Chaudhuri
Department of Physiology, Burdwan Medical College and Hospital, Krishnasayar South, Borehat, Burdwan - 713 102, West Bengal
India
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DOI: 10.4103/1319-6308.149528

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Background: Pulmonary involvement in rheumatoid arthritis (RA) is frequent although not always clinically recognized. Objectives: The present study was conducted to measure the alterations of lung function parameters with the help of pulmonary function tests in patients of RA in a semi-urban population of a developing country. Materials and Methods: This pilot study was conducted in a time span of 1 year on 156 subjects in Burdwan Medical College after taking Institutional Ethical Clearance and informed consent of the subjects. A total of 106 diagnosed cases of RA was taken as cases, and 50 normal individuals were selected as a control. Different parameters studied were forced vital capacity (FVC), FVC%, forced expiratory volume in 1 s (FEV1), FEV1%, FEV1/FVC, forced expiratory flow (FEF25-75), FEF25-75%, peak expiratory flow rate (PEFR), PEFR%. Results: FVC, FEV1, FEV1/FVC, FEF25-75, PEFR, and PEFR% were significantly decreased (P < 0.05) in cases. But there was no significant difference in FVC%, FEV1%, and FEF25-75%. Among RA patients, 56.6% were normal, 15.09% had obstructive lung diseases (OLD), and 28.3% had restrictive lung diseases (RLDs). Conclusions: RA was found to be of significant importance in the development of restrictive, as well as OLD. RLD was significantly higher in patients positive for rheumatoid factor and anticyclic citrullinated peptides antibody. Since RA, affects general population with a prevalence of 0.5-1% and lung function gets affected in 30-40% of cases, the patients might be screened for respiratory abnormalities from the time of diagnosis using spirometry.


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