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ORIGINAL ARTICLE
Year : 2015  |  Volume : 15  |  Issue : 2  |  Page : 187-192

A study to detect abnormalities in nerve conduction velocities in newly diagnosed hypothyroid subjects and find its correlation with free T 4 levels in a rural population of eastern India


1 Department of Physiology, Medical College and Hospital, Kolkata, India
2 Department of Physiology, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
3 Department of Physiology, RG Kar Medical College and Hospital, Kolkata, India
4 Department of Physiology, Sagar Dutta Medical College and Hospital, Kolkata, India

Correspondence Address:
Arunima Chaudhuri
Krishnasayar South, Borehat, Burdwan - 713 102, West Bengal
India
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DOI: 10.4103/1319-6308.156371

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Background: Deposition of glycosaminoglycans in nerves and soft tissues surrounding them result in axonal degeneration and secondary segmental demyelination and forms the pathological basis of alterations in peripheral nerve function in thyroid hormone deficiency. Aims: To detect abnormalities in nerve conduction velocities (NCVs) in newly diagnosed hypothyroid subjects and find its correlation with free thyroxine (FT4) levels in a rural population of eastern India. Materials and Methods: This cross-sectional study was carried in a tertiary care hospital of eastern India on 50 newly diagnosed hypothyroid subjects, selected as study group and 50 healthy subjects as control. Screening tests for thyroid hormone (Serum thyroid-stimulating hormone [TSH] and FT4 were estimated) was done on 512 adults and among them 50 were hypothyroid. NCV analysis was performed. Results: TSH values were 50.04 μIU//ml ± 14.61 and FT4 values 0.56 ng/dl ± 0.15 in hypothyroids and TSH values were 2.17 μIU//ml ± 0.57 and FT4 values were 1.46 ng/dl ± 0.27 respectively in euthyroid subjects. Forty-one (82%) patients out of 50 hypothyroid patients had presented with symptoms of hypothyroidism. NCV parameters were higher in the Euthyroid group than the hypothyroid group. FT4 values were positively correlated with NCVs. Conclusions: Screening tests need to be implemented in Indian population for early detection of thyroid disorders and electrophysiological studies are to be conducted in hypothyroid subjects to detect peripheral neuropathy because early detection can reverse the condition by treatment.


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